Immunogenicity Evaluation of Recombinant Edible Vaccine Candidate Containing HER2-MUC1 against Breast Cancer.
Identifieur interne : 000247 ( Main/Exploration ); précédent : 000246; suivant : 000248Immunogenicity Evaluation of Recombinant Edible Vaccine Candidate Containing HER2-MUC1 against Breast Cancer.
Auteurs : Mahdieh Mehrab Mohseni [Iran] ; Jafar Amani [Iran] ; Mahdi Fasihi Ramandi [Iran] ; Forouzandeh Mahjoubi [Iran] ; Mahyat Jafaria [Iran] ; Ali Hatef Salmanian [Iran]Source :
- Iranian journal of allergy, asthma, and immunology [ 1735-5249 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Femelle (MeSH), Graines (immunologie), Immunisation (méthodes), Immunoglobuline A (immunologie), Immunoglobuline G (immunologie), Interféron gamma (immunologie), Modèles animaux (MeSH), Mucine-1 (immunologie), Protéines de fusion recombinantes (immunologie), Racines de plante (immunologie), Récepteur ErbB-2 (immunologie), Souris (MeSH), Souris de lignée BALB C (MeSH), Tumeurs du sein (immunologie), Tumeurs du sein (métabolisme), Vaccination (méthodes), Vaccins anticancéreux (immunologie), Vaccins comestibles (immunologie), Végétaux génétiquement modifiés (immunologie).
- MESH :
- immunologie : Graines, Immunoglobuline A, Immunoglobuline G, Interféron gamma, Mucine-1, Protéines de fusion recombinantes, Racines de plante, Récepteur ErbB-2, Tumeurs du sein, Vaccins anticancéreux, Vaccins comestibles, Végétaux génétiquement modifiés.
- métabolisme : Tumeurs du sein.
- méthodes : Immunisation, Vaccination.
- Animaux, Femelle, Modèles animaux, Souris, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Animals (MeSH), Breast Neoplasms (immunology), Breast Neoplasms (metabolism), Cancer Vaccines (immunology), Female (MeSH), Immunization (methods), Immunoglobulin A (immunology), Immunoglobulin G (immunology), Interferon-gamma (immunology), Mice (MeSH), Mice, Inbred BALB C (MeSH), Models, Animal (MeSH), Mucin-1 (immunology), Plant Roots (immunology), Plants, Genetically Modified (immunology), Receptor, ErbB-2 (immunology), Recombinant Fusion Proteins (immunology), Seeds (immunology), Vaccination (methods), Vaccines, Edible (immunology).
- MESH :
- chemical , immunology : Cancer Vaccines, Immunoglobulin A, Immunoglobulin G, Interferon-gamma, Mucin-1, Receptor, ErbB-2, Recombinant Fusion Proteins, Vaccines, Edible.
- immunology : Breast Neoplasms, Plant Roots, Plants, Genetically Modified, Seeds.
- metabolism : Breast Neoplasms.
- methods : Immunization, Vaccination.
- Animals, Female, Mice, Mice, Inbred BALB C, Models, Animal.
Abstract
Human epithelial growth factor receptor2 (Her2) and polymorphic epithelial mucin (MUC1) are tumor-associated antigens that have been extensively investigated in adenocarcinomas. Generally, each of these molecules was used separately for diagnosis of adenocarcinomas and as an injective vaccines in cancer therapy researches, but not in the chimeric form as an edible immunogen. In this study, Her2, MUC1, and a novel fusion structure were expressed in the seeds and hairy roots of transgenic plants appropriately. The mice groups were immunized either by feeding of transgenic seeds or hairy roots. All immunized groups showed a considerable rise in anti-glycoprotein serum IgG and IgA, and IFNɣ cytokine. However, the animals received chimeric protein showed significant higher immune responses in comparison to ones received one of these immunogen. The results indicated that the oral immunization of an animal model with transgenic plants could effectively elicit immune responses against two major tumor-associated antigens.
DOI: 10.18502/ijaai.v18i5.1921
PubMed: 32245295
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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M-jafari@nigeb.ac.ir.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Agricultural Biotechnology, National Institute for Genetic Engineering and Biotechnology (NIGEB), Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Salmanian, Ali Hatef" sort="Salmanian, Ali Hatef" uniqKey="Salmanian A" first="Ali Hatef" last="Salmanian">Ali Hatef Salmanian</name><affiliation wicri:level="1"><nlm:affiliation>Department of Agricultural Biotechnology, National Institute for Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran. salman@nigeb.ac.ir.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Agricultural Biotechnology, National Institute for Genetic Engineering and Biotechnology (NIGEB), Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author></analytic><series><title level="j">Iranian journal of allergy, asthma, and immunology</title><idno type="eISSN">1735-5249</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Breast Neoplasms (immunology)</term><term>Breast Neoplasms (metabolism)</term><term>Cancer Vaccines (immunology)</term><term>Female (MeSH)</term><term>Immunization (methods)</term><term>Immunoglobulin A (immunology)</term><term>Immunoglobulin G (immunology)</term><term>Interferon-gamma (immunology)</term><term>Mice (MeSH)</term><term>Mice, Inbred BALB C (MeSH)</term><term>Models, Animal (MeSH)</term><term>Mucin-1 (immunology)</term><term>Plant Roots (immunology)</term><term>Plants, Genetically Modified (immunology)</term><term>Receptor, ErbB-2 (immunology)</term><term>Recombinant Fusion Proteins (immunology)</term><term>Seeds (immunology)</term><term>Vaccination (methods)</term><term>Vaccines, Edible (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Femelle (MeSH)</term><term>Graines (immunologie)</term><term>Immunisation (méthodes)</term><term>Immunoglobuline A (immunologie)</term><term>Immunoglobuline G (immunologie)</term><term>Interféron gamma (immunologie)</term><term>Modèles animaux (MeSH)</term><term>Mucine-1 (immunologie)</term><term>Protéines de fusion recombinantes (immunologie)</term><term>Racines de plante (immunologie)</term><term>Récepteur ErbB-2 (immunologie)</term><term>Souris (MeSH)</term><term>Souris de lignée BALB C (MeSH)</term><term>Tumeurs du sein (immunologie)</term><term>Tumeurs du sein (métabolisme)</term><term>Vaccination (méthodes)</term><term>Vaccins anticancéreux (immunologie)</term><term>Vaccins comestibles (immunologie)</term><term>Végétaux génétiquement modifiés (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Cancer Vaccines</term><term>Immunoglobulin A</term><term>Immunoglobulin G</term><term>Interferon-gamma</term><term>Mucin-1</term><term>Receptor, ErbB-2</term><term>Recombinant Fusion Proteins</term><term>Vaccines, Edible</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Graines</term><term>Immunoglobuline A</term><term>Immunoglobuline G</term><term>Interféron gamma</term><term>Mucine-1</term><term>Protéines de fusion recombinantes</term><term>Racines de plante</term><term>Récepteur ErbB-2</term><term>Tumeurs du sein</term><term>Vaccins anticancéreux</term><term>Vaccins comestibles</term><term>Végétaux génétiquement modifiés</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Breast Neoplasms</term><term>Plant Roots</term><term>Plants, Genetically Modified</term><term>Seeds</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunization</term><term>Vaccination</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Immunisation</term><term>Vaccination</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Models, Animal</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Modèles animaux</term><term>Souris</term><term>Souris de lignée BALB C</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Human epithelial growth factor receptor2 (Her2) and polymorphic epithelial mucin (MUC1) are tumor-associated antigens that have been extensively investigated in adenocarcinomas. Generally, each of these molecules was used separately for diagnosis of adenocarcinomas and as an injective vaccines in cancer therapy researches, but not in the chimeric form as an edible immunogen. In this study, Her2, MUC1, and a novel fusion structure were expressed in the seeds and hairy roots of transgenic plants appropriately. The mice groups were immunized either by feeding of transgenic seeds or hairy roots. All immunized groups showed a considerable rise in anti-glycoprotein serum IgG and IgA, and IFNɣ cytokine. However, the animals received chimeric protein showed significant higher immune responses in comparison to ones received one of these immunogen. The results indicated that the oral immunization of an animal model with transgenic plants could effectively elicit immune responses against two major tumor-associated antigens.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32245295</PMID><DateCompleted><Year>2020</Year><Month>05</Month><Day>29</Day></DateCompleted><DateRevised><Year>2020</Year><Month>05</Month><Day>29</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1735-5249</ISSN><JournalIssue CitedMedium="Internet"><Volume>18</Volume><Issue>5</Issue><PubDate><Year>2019</Year><Month>Oct</Month><Day>23</Day></PubDate></JournalIssue><Title>Iranian journal of allergy, asthma, and immunology</Title><ISOAbbreviation>Iran J Allergy Asthma Immunol</ISOAbbreviation></Journal><ArticleTitle>Immunogenicity Evaluation of Recombinant Edible Vaccine Candidate Containing HER2-MUC1 against Breast Cancer.</ArticleTitle><Pagination><MedlinePgn>511-522</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.18502/ijaai.v18i5.1921</ELocationID><Abstract><AbstractText>Human epithelial growth factor receptor2 (Her2) and polymorphic epithelial mucin (MUC1) are tumor-associated antigens that have been extensively investigated in adenocarcinomas. Generally, each of these molecules was used separately for diagnosis of adenocarcinomas and as an injective vaccines in cancer therapy researches, but not in the chimeric form as an edible immunogen. In this study, Her2, MUC1, and a novel fusion structure were expressed in the seeds and hairy roots of transgenic plants appropriately. The mice groups were immunized either by feeding of transgenic seeds or hairy roots. All immunized groups showed a considerable rise in anti-glycoprotein serum IgG and IgA, and IFNɣ cytokine. However, the animals received chimeric protein showed significant higher immune responses in comparison to ones received one of these immunogen. The results indicated that the oral immunization of an animal model with transgenic plants could effectively elicit immune responses against two major tumor-associated antigens.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mehrab Mohseni</LastName><ForeName>Mahdieh</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Agricultural Biotechnology, National Institute for Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran. mehrab@nigeb.ac.ir.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amani</LastName><ForeName>Jafar</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran. jafar.amani@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fasihi Ramandi</LastName><ForeName>Mahdi</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. fasihi.m@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mahjoubi</LastName><ForeName>Forouzandeh</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Medical Biotechnology, National Institute for Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran. frouz@nigeb.ac.ir.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jafaria</LastName><ForeName>Mahyat</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Agricultural Biotechnology, National Institute for Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran. M-jafari@nigeb.ac.ir.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Salmanian</LastName><ForeName>Ali Hatef</ForeName><Initials>AH</Initials><AffiliationInfo><Affiliation>Department of Agricultural Biotechnology, National Institute for Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran. salman@nigeb.ac.ir.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>10</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>Iran</Country><MedlineTA>Iran J Allergy Asthma Immunol</MedlineTA><NlmUniqueID>101146178</NlmUniqueID><ISSNLinking>1735-1502</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019496">Cancer Vaccines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007070">Immunoglobulin A</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018396">Mucin-1</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011993">Recombinant Fusion Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D022462">Vaccines, Edible</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C577056">muc1 protein, mouse</NameOfSubstance></Chemical><Chemical><RegistryNumber>82115-62-6</RegistryNumber><NameOfSubstance UI="D007371">Interferon-gamma</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.10.1</RegistryNumber><NameOfSubstance UI="C524056">Erbb2 protein, mouse</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.10.1</RegistryNumber><NameOfSubstance UI="D018719">Receptor, ErbB-2</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001943" MajorTopicYN="N">Breast Neoplasms</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019496" MajorTopicYN="N">Cancer Vaccines</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007114" MajorTopicYN="N">Immunization</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007070" MajorTopicYN="N">Immunoglobulin A</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007371" MajorTopicYN="N">Interferon-gamma</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008807" MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D023421" MajorTopicYN="N">Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018396" MajorTopicYN="N">Mucin-1</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018517" MajorTopicYN="N">Plant Roots</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D030821" MajorTopicYN="N">Plants, Genetically Modified</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018719" MajorTopicYN="N">Receptor, ErbB-2</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011993" MajorTopicYN="N">Recombinant Fusion Proteins</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012639" MajorTopicYN="N">Seeds</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014611" MajorTopicYN="N">Vaccination</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D022462" MajorTopicYN="N">Vaccines, Edible</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Breast cancer</Keyword><Keyword MajorTopicYN="N">Edible vaccine</Keyword><Keyword MajorTopicYN="N">HER2</Keyword><Keyword MajorTopicYN="N">Immunogen</Keyword><Keyword MajorTopicYN="N">MUC1</Keyword><Keyword MajorTopicYN="N">Transgenic plant</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>12</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>05</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>5</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32245295</ArticleId><ArticleId IdType="doi">10.18502/ijaai.v18i5.1921</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Iran</li></country></list><tree><country name="Iran"><noRegion><name sortKey="Mehrab Mohseni, Mahdieh" sort="Mehrab Mohseni, Mahdieh" uniqKey="Mehrab Mohseni M" first="Mahdieh" last="Mehrab Mohseni">Mahdieh Mehrab Mohseni</name></noRegion><name sortKey="Amani, Jafar" sort="Amani, Jafar" uniqKey="Amani J" first="Jafar" last="Amani">Jafar Amani</name><name sortKey="Fasihi Ramandi, Mahdi" sort="Fasihi Ramandi, Mahdi" uniqKey="Fasihi Ramandi M" first="Mahdi" last="Fasihi Ramandi">Mahdi Fasihi Ramandi</name><name sortKey="Jafaria, Mahyat" sort="Jafaria, Mahyat" uniqKey="Jafaria M" first="Mahyat" last="Jafaria">Mahyat Jafaria</name><name sortKey="Mahjoubi, Forouzandeh" sort="Mahjoubi, Forouzandeh" uniqKey="Mahjoubi F" first="Forouzandeh" last="Mahjoubi">Forouzandeh Mahjoubi</name><name sortKey="Salmanian, Ali Hatef" sort="Salmanian, Ali Hatef" uniqKey="Salmanian A" first="Ali Hatef" last="Salmanian">Ali Hatef Salmanian</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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